The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo

@article{Wagner2008TheWT,
  title={The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo},
  author={Norbert Wagner and Jean François Michiels and Andreas Schedl and K-D Wagner},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={3662-3672}
}
Vascularization is an important step in tumour growth. Although a variety of molecules, for example, VEGF, ETS-1 or nestin have been implicated in tumour angiogenesis, the molecular mechanisms of vessel formation are not fully characterized. We showed that the Wilms' tumour suppressor WT1 activates nestin during development. Here we tested whether WT1 might also be involved in tumour angiogenesis. Endothelial WT1 expression was detected in 95% of 113 tumours of different origin. To analyse the… CONTINUE READING

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Role of the Wilms’ tumour transcription factor, Wt1, in blood vessel formation

Pflügers Archiv - European Journal of Physiology • 2008
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