The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells.

@article{Liu2001TheWT,
  title={The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells.},
  author={Xuebin Liu and Longcai Gong and Lucie Y. Guo and Yoko U Katagiri and H Jiang and Zhepeng Wang and Anjeanette C. Johnson and Gordon Guroff},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 7},
  pages={5068-73}
}
Recently, we characterized the rat epidermal growth factor receptor (EGFR) promoter and demonstrated that TCC repeat sequences are required for the down-regulation of EGFR by nerve growth factor (NGF) in PC12 cells. In this study, we report that the Wilms' tumor gene product WT1, a zinc finger transcription factor, is able to enhance the activity of the rat EGFR promoter in cotransfection assays. Gel mobility shift assays demonstrate that WT1 binds to the TCC repeat sequences of the rat EGFR… CONTINUE READING
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Bioessays

  • M Little, G Holmes, P Walsh
  • Bioessays
  • 1999

Cell

  • S B Lee, K Huang, +9 authors J D Harber
  • Cell
  • 1999

Int. Rev. Cytol

  • A L Menke, A J Van Der Eb, A G Jochemsen
  • Int. Rev. Cytol
  • 1998

J. Biol. Chem

  • C Heckman, E Mochon, M Arcinas, L M Boxer
  • J. Biol. Chem
  • 1997

Biochim. Biophys. Acta

  • J C Reddy, J D Licht
  • Biochim. Biophys. Acta
  • 1996

Embo J

  • C Englert, X Hou, +6 authors D A Haber
  • EMBO J
  • 1995

Neuron

  • G Rusanescu, H Qi, S M Thomas, J S Brugge, S Halegoua
  • Neuron
  • 1995

Blood

  • M Sekiya, M Adachi, Y Hinoda, K Imaim, A Yachi
  • Blood
  • 1994

Am. J. Pathol

  • H Kikuchi, Y Akasaka, +4 authors J Hata
  • Am. J. Pathol
  • 1992

Mol. Cell. Biol

  • J Szeberenyi, H Cai, G M Cooper
  • Mol. Cell. Biol
  • 1990

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