The Wilms' tumor 1 gene: oncogene or tumor suppressor gene?

@article{Menke1998TheWT,
  title={The Wilms' tumor 1 gene: oncogene or tumor suppressor gene?},
  author={Aswin L. Menke and Alex J van der Eb and Aart G. Jochemsen},
  journal={International review of cytology},
  year={1998},
  volume={181},
  pages={151-212}
}
The Wilms' tumor 1 (wt1) gene is one of at least three genes that are involved in the development of Wilms' tumor, a pediatric kidney cancer. The expression pattern of the gene indicates that wt1 not only plays a role during kidney development but is also involved in the development and homeostasis of several other tissues. The physiological function of the gene, however, remains to be elucidated. The gene products have been implicated in many processes like proliferation, differentiation, and… CONTINUE READING