The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci

  title={The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci},
  author={Raymond A. Poot and Ludmila Bozhenok and Debbie L. C. van den Berg and S. Steffensen and Fernando Rog{\'e}rio Lara Ferreira and Margaret Grimaldi and Nick Gilbert and Jo{\~a}o Silva Mendonça Sim{\~a}o Ferreira and Patrick D Varga-Weisz},
  journal={Nature Cell Biology},
Chromatin states have to be faithfully duplicated during DNA replication to maintain cell identity. It is unclear whether or how ATP-dependent chromatin-remodelling factors are involved in this process. Here we provide evidence that the Williams syndrome transcription factor (WSTF) is targeted to replication foci through direct interaction with the DNA clamp PCNA, an important coordinator of DNA and chromatin replication. WSTF, in turn, recruits imitation switch (ISWI)-type nucleosome… CONTINUE READING

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