The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci

@article{Poot2004TheWS,
  title={The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci},
  author={Raymond A. Poot and Ludmila Bozhenok and Debbie L. C. van den Berg and S. Steffensen and Fernando Rog{\'e}rio Lara Ferreira and Margaret Grimaldi and Nick Gilbert and Jo{\~a}o Silva Mendonça Sim{\~a}o Ferreira and Patrick D Varga-Weisz},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={1236-1244}
}
Chromatin states have to be faithfully duplicated during DNA replication to maintain cell identity. It is unclear whether or how ATP-dependent chromatin-remodelling factors are involved in this process. Here we provide evidence that the Williams syndrome transcription factor (WSTF) is targeted to replication foci through direct interaction with the DNA clamp PCNA, an important coordinator of DNA and chromatin replication. WSTF, in turn, recruits imitation switch (ISWI)-type nucleosome… CONTINUE READING

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Nucleosome assembly and epigenetic inheritance

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View 4 Excerpts
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Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF).

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 8 Excerpts
Highly Influenced

Cell cycle regulation of chromatin at an origin of DNA replication.

The EMBO journal • 2005
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Functional diversity of ISWI complexes.

Biochemistry and cell biology = Biochimie et biologie cellulaire • 2004

Epigenomic replication: linking epigenetics to DNA replication.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2003

Linking epigenetics to DNA replication

A. J. McNairn, Gilbert, D. M. Epigenomic replication
Bioessays 25, 647–656 • 2003

The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams Syndrome

H Kitagawa
Cell 113, • 2003

a dancer with many partners

G. Maga, Hubscher, U. Proliferating cell nuclear antigen PCNA
J. Cell Sci. 116, 3051–3060 • 2003

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