The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

@article{Farh2005TheWI,
  title={The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution},
  author={Kyle Kai-How Farh and Andrew Grimson and Calvin H. Jan and Benjamin P. Lewis and Wendy K. Johnston and Lee P. Lim and Christopher B. Burge and David P. Bartel},
  journal={Science},
  year={2005},
  volume={310},
  pages={1817 - 1821}
}
Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are often highly expressed at developmental stages before miRNA expression and that their levels tend to fall as the miRNA that targets them begins to accumulate. Nonconserved sites, which outnumber the conserved sites 10 to 1, also mediate repression. As a consequence, genes preferentially expressed at the same time and place as a… 

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