The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H+-ATPase

@article{Kane2006TheWW,
  title={The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H+-ATPase},
  author={Patricia M. Kane},
  journal={Microbiology and Molecular Biology Reviews},
  year={2006},
  volume={70},
  pages={177 - 191}
}
  • P. Kane
  • Published 1 March 2006
  • Biology
  • Microbiology and Molecular Biology Reviews
SUMMARY All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in organelle acidification. Not only is the structure of V-ATPases highly conserved among eukaryotes, but there are also many regulatory mechanisms that are similar between fungi and higher eukaryotes. These mechanisms allow cells both to regulate the pHs of different compartments and to respond to changing extracellular conditions. The Saccharomyces cerevisiae V-ATPase has emerged as an important… 

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