The Werner syndrome protein is a DNA helicase

  title={The Werner syndrome protein is a DNA helicase},
  author={M. Gray and Jiang-Cheng Shen and A. Kamath-Loeb and A. Blank and B. Sopher and G. Martin and J. Oshima and L. Loeb},
  journal={Nature Genetics},
  • M. Gray, Jiang-Cheng Shen, +5 authors L. Loeb
  • Published 1997
  • Biology, Medicine
  • Nature Genetics
  • Werner syndrome (WS) is an uncommon autosomal recessive disorder characterized by premature aging. The clinical manifestations of WS, including atherosclerosis and osteoporosis, appear early in adulthood, and death in the fourth to sixth decade commonly ensues from myocardial infarction or cancer1,2. In accord with the aging phenotype, cells from WS patients have a reduced replicative life span in culture3. Genomic instability is observed at the cytogenetic level in the form of chromosome… CONTINUE READING
    562 Citations
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    • PDF
    The Werner syndrome helicase-nuclease--one protein, many mysteries.
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    • Biology, Medicine
    • Science of aging knowledge environment : SAGE KE
    • 2002
    • 25
    • PDF
    Werner Syndrome Protein and DNA Replication
    • 14
    • PDF
    Current advances in unraveling the function of the Werner syndrome protein.
    • 95
    • PDF
    The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
    • 167
    • PDF
    Enzymatic mechanism of the WRN helicase/nuclease.
    • 36
    The Werner syndrome protein is involved in RNA polymerase II transcription.
    • 136
    • PDF
    The Werner syndrome protein at the crossroads of DNA repair and apoptosis
    • L. Comai, B. Li
    • Biology, Medicine
    • Mechanisms of Ageing and Development
    • 2004
    • 39
    • PDF


    Positional Cloning of the Werner's Syndrome Gene
    • 1,603
    • PDF
    Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.
    • 145
    Mutator phenotype of Werner syndrome is characterized by extensive deletions.
    • 426
    • PDF
    The Bloom's syndrome gene product is homologous to RecQ helicases
    • 1,293
    • PDF
    RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6.
    • 233
    • PDF
    Homozygous and compound heterozygous mutations at the Werner syndrome locus.
    • 101
    • PDF
    Excess of rare cancers in Werner syndrome (adult progeria).
    • M. Goto, R. Miller, Y. Ishikawa, H. Sugano
    • Medicine
    • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
    • 1996
    • 405
    • PDF