The Werner syndrome protein is a DNA helicase

@article{Gray1997TheWS,
  title={The Werner syndrome protein is a DNA helicase},
  author={M. Gray and Jiang-Cheng Shen and A. Kamath-Loeb and A. Blank and B. Sopher and G. Martin and J. Oshima and L. Loeb},
  journal={Nature Genetics},
  year={1997},
  volume={17},
  pages={100-103}
}
  • M. Gray, Jiang-Cheng Shen, +5 authors L. Loeb
  • Published 1997
  • Biology, Medicine
  • Nature Genetics
    • Werner syndrome (WS) is an uncommon autosomal recessive disorder characterized by premature aging. The clinical manifestations of WS, including atherosclerosis and osteoporosis, appear early in adulthood, and death in the fourth to sixth decade commonly ensues from myocardial infarction or cancer1,2. In accord with the aging phenotype, cells from WS patients have a reduced replicative life span in culture3. Genomic instability is observed at the cytogenetic level in the form of chromosome… CONTINUE READING
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