The Warburg effect: insights from the past decade.

  title={The Warburg effect: insights from the past decade.},
  author={Mohita Upadhyay and Jasmine Samal and Manish Kandpal and Om Vir Singh and Perumal Vivekanandan},
  journal={Pharmacology & therapeutics},
  volume={137 3},
Several decades ago, Otto Warburg discovered that cancer cells produce energy predominantly by glycolysis; a phenomenon now termed "Warburg effect". Warburg linked mitochondrial respiratory defects in cancer cells to aerobic glycolysis; this theory of his gradually lost its importance with the lack of conclusive evidence confirming the presence of mitochondrial defects in cancer cells. Scientists began to believe that this altered mechanism of energy production in cancer cells was more of an… CONTINUE READING
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