The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor.

@article{Dagil2012TheWM,
  title={The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor.},
  author={Robert Dagil and Maiken J Knudsen and Johan G. Olsen and Charlotte O'Shea and Magnus Franzmann and Vincent Goffin and Kaare Teilum and Jens Breinholt and Birthe B Kragelund},
  journal={Structure},
  year={2012},
  volume={20 2},
  pages={270-82}
}
The prolactin receptor (PRLR) is activated by binding of prolactin in a 2:1 complex, but the activation mechanism is poorly understood. PRLR has a conserved WSXWS motif generic to cytokine class I receptors. We have determined the nuclear magnetic resonance solution structure of the membrane proximal domain of the human PRLR and find that the tryptophans of the motif adopt a T-stack conformation in the unbound state. By contrast, in the hormone bound state, a Trp/Arg-ladder is formed. The… CONTINUE READING

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References

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Showing 1-10 of 66 references

Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone

J. van Agthoven, C. Zhang, +6 authors I. Broutin
J. Mol. Biol • 2010
View 4 Excerpts
Highly Influenced

Activation of receptor-associated tyrosine kinase JAK2 by prolactin.

The Journal of biological chemistry • 1994
View 4 Excerpts
Highly Influenced

1992).Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoi282 Structure

H. F. Lodish
2012

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