The WNT signaling pathway contributes to dectin-1-dependent inhibition of Toll-like receptor-induced inflammatory signature.

@article{Trinath2014TheWS,
  title={The WNT signaling pathway contributes to dectin-1-dependent inhibition of Toll-like receptor-induced inflammatory signature.},
  author={Jamma Trinath and Sahana Holla and Kasturi Mahadik and Praveen Prakhar and Vikas Shyamraj Singh and Kithiganahalli Narayanaswamy Balaji},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 23},
  pages={4301-14}
}
Macrophages regulate cell fate decisions during microbial challenges by carefully titrating signaling events activated by innate receptors such as dectin-1 or Toll-like receptors (TLRs). Here, we demonstrate that dectin-1 activation robustly dampens TLR-induced proinflammatory signature in macrophages. Dectin-1 induced the stabilization of β-catenin via spleen tyrosine kinase (Syk)-reactive oxygen species (ROS) signals, contributing to the expression of WNT5A. Subsequently, WNT5A-responsive… CONTINUE READING
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