The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.


Neovessel formation is a complex process governed by the orchestrated action of multiple factors that regulate EC specification and dynamics within a growing vascular tree. These factors have been widely exploited to develop therapies for angiogenesis-related diseases such as diabetic retinopathy and tumor growth and metastasis. WNT signaling has been… (More)
DOI: 10.1172/JCI42556