The WNKs: atypical protein kinases with pleiotropic actions.

  title={The WNKs: atypical protein kinases with pleiotropic actions.},
  author={James A. McCormick and David H Ellison},
  journal={Physiological reviews},
  volume={91 1},
WNKs are serine/threonine kinases that comprise a unique branch of the kinome. They are so-named owing to the unusual placement of an essential catalytic lysine. WNKs have now been identified in diverse organisms. In humans and other mammals, four genes encode WNKs. WNKs are widely expressed at the message level, although data on protein expression is more limited. Soon after the WNKs were identified, mutations in genes encoding WNK1 and -4 were determined to cause the human disease familial… CONTINUE READING
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