The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

  title={The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters},
  author={Dario R Alessi and Jinwei Zhang and Arjun Khanna and Thomas Hochd{\"o}rfer and Yuze Shang and Kristopher Thomas Kahle},
  journal={Science Signaling},
The WNK-SPAK/OSR1 kinase complex is composed of the kinases WNK (with no lysine) and SPAK (SPS1-related proline/alanine-rich kinase) or the SPAK homolog OSR1 (oxidative stress–responsive kinase 1). The WNK family senses changes in intracellular Cl− concentration, extracellular osmolarity, and cell volume and transduces this information to sodium (Na+), potassium (K+), and chloride (Cl−) cotransporters [collectively referred to as CCCs (cation-chloride cotransporters)] and ion channels to… CONTINUE READING
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