The WAVE2 Complex Regulates Actin Cytoskeletal Reorganization and CRAC-Mediated Calcium Entry during T Cell Activation

@article{Nolz2006TheWC,
  title={The WAVE2 Complex Regulates Actin Cytoskeletal Reorganization and CRAC-Mediated Calcium Entry during T Cell Activation},
  author={Jeffrey C Nolz and Timothy S. Gomez and Peimin Zhu and Shuixing Li and Ricardo B. Medeiros and Yoji Shimizu and Janis K Burkhardt and Bruce D Freedman and Daniel D Billadeau},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={24-34}
}
BACKGROUND The engagement of the T cell receptor results in actin cytoskeletal reorganization at the immune synapse (IS) and the triggering of biochemical signaling cascades leading to gene regulation and, ultimately, cellular activation. Recent studies have identified the WAVE family of proteins as critical mediators of Rac1-induced actin reorganization in other cell types. However, whether these proteins participate in actin reorganization at the IS or signaling pathways in T cells has not… CONTINUE READING

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