The WASP–WAVE protein network: connecting the membrane to the cytoskeleton

  title={The WASP–WAVE protein network: connecting the membrane to the cytoskeleton},
  author={Tadaomi Takenawa and Shiro Suetsugu},
  journal={Nature Reviews Molecular Cell Biology},
Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein (WAVE) family proteins are scaffolds that link upstream signals to the activation of the ARP2/3 complex, leading to a burst of actin polymerization. ARP2/3-complex-mediated actin polymerization is crucial for the reorganization of the actin cytoskeleton at the cell cortex for processes such as cell movement, vesicular trafficking and pathogen infection. Large families of membrane-binding proteins were recently… CONTINUE READING
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