The WASP–WAVE protein network: connecting the membrane to the cytoskeleton

@article{Takenawa2007TheWP,
  title={The WASP–WAVE protein network: connecting the membrane to the cytoskeleton},
  author={Tadaomi Takenawa and Shiro Suetsugu},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={37-48}
}
Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein (WAVE) family proteins are scaffolds that link upstream signals to the activation of the ARP2/3 complex, leading to a burst of actin polymerization. ARP2/3-complex-mediated actin polymerization is crucial for the reorganization of the actin cytoskeleton at the cell cortex for processes such as cell movement, vesicular trafficking and pathogen infection. Large families of membrane-binding proteins were recently… CONTINUE READING
Highly Influential
This paper has highly influenced 43 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
361 Extracted Citations
148 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 361 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 148 references

Optimization of WAVE 2complexinduced actin polymerization by membrane - bound IRSp 53 , PIP 3 , and Rac

  • C. F. Stovold, T. H. Millard, L. M. Machesky
  • J . Cell Biol .
  • 2006

The RACbinding domain / IRSP 53MIM homology domain of IRSP 53 induces RACdependent membrane deformation

  • S. Govind, R. Kozma, C. Monfries, L. Lim, S. Ahmed
  • J . Biol . Chem .
  • 2006

Similar Papers

Loading similar papers…