The Vroman effect: a molecular level description of fibrinogen displacement.

  title={The Vroman effect: a molecular level description of fibrinogen displacement.},
  author={Seung-Yong Jung and S Lim and Fernando Albertorio and Gibum Kim and Marc C. Gurau and Richard D. Yang and Matthew A. Holden and Paul S Cremer},
  journal={Journal of the American Chemical Society},
  volume={125 42},
The molecular level details of the displacement of surface adsorbed fibrinogen from silica substrates were studied by atomic force microscopy, immunochemical assays, fluorescence microscopy, and vibrational sum frequency spectroscopy. The results showed that human plasma fibrinogen (HPF) can be readily displaced from the interface by other plasma proteins near neutral pH because the positively charged alpha C domains on HPF sit between the rest of the macromolecule and the underlying surface… CONTINUE READING


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