The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVET.

@article{Lachmann2014TheVT,
  title={The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVET.},
  author={Jens Lachmann and Elina Glaubke and Patrick S Moore and Christian Ungermann},
  journal={Cellular logistics},
  year={2014},
  volume={4 4},
  pages={e970840}
}
Membrane fusion in the endocytic pathway is mediated by a protein machinery consistent of Rab GTPases, tethering factors and SNAREs. In yeast, the endosomal CORVET and lysosomal HOPS tethering complexes share 4 of their 6 subunits. The 2 additional subunits in each complex - Vps3 and Vps8 for CORVET, and the homologous Vps39 and Vps41 for HOPS - bind directly to Rab5 and Rab7, respectively. In humans, all subunits for HOPS have been described. However, human CORVET remains poorly characterized… CONTINUE READING