The Voltage Sensor Of Cnga1 Channels Becomes Functional When The Hydrophobic Bond Between Phe380 And Leu356 Is Impaired

@article{Mazzolini2009TheVS,
  title={The Voltage Sensor Of Cnga1 Channels Becomes Functional When The Hydrophobic Bond Between Phe380 And Leu356 Is Impaired},
  author={M. Mazzolini},
  journal={Biophysical Journal},
  year={2009},
  volume={96}
}
The super-family of voltage gated ionic channels comprises usual voltage-dependent Na+, K+ and Ca2+ channels, but also cyclic nucleotide gated (CNG) channels which are not voltage dependent. Voltage dependency in this super-family of ion channels is caused by the motion of the voltage sensor, identified as a positively charged transmembrane helix, referred to as S4. This voltage sensor is present in all voltage gated Na+, K+ and Ca2+ channels as well as in CNG channels, and why CNG channels are… Expand