The Vitamin D Receptor Gene Bat (Cca) Haplotype Impairs the Response to Pegylated-Interferon/ Ribavirin-Based Therapy in Chronic Hepatitis C Patients

@article{Baur2012TheVD,
  title={The Vitamin D Receptor Gene Bat (Cca) Haplotype Impairs the Response to Pegylated-Interferon/ Ribavirin-Based Therapy in Chronic Hepatitis C Patients},
  author={Katharina Baur and Joachim C Mertens and Johannes Schmitt and Rika Iwata and Bruno Stieger and Pascal Frei and Burkhardt Seifert and Heike A Bischoff Ferrari and Arnold von Eckardstein and Beat M{\"u}llhaupt and Andreas Geier},
  journal={Antiviral Therapy},
  year={2012},
  volume={17},
  pages={541 - 547}
}
Background Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of the vitamin D receptor (NR1I1) haplotype and combined effects of plasma vitamin D levels in a well-described cohort of hepatitis C patients. Methods A total of 155 chronic hepatitis C patients were recruited from the Swiss Hepatitis C Cohort Study for NR1I1 genotyping and… 

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