• Corpus ID: 198897781

The Virtual Patch Clamp: Imputing C. elegans Membrane Potentials from Calcium Imaging

  title={The Virtual Patch Clamp: Imputing C. elegans Membrane Potentials from Calcium Imaging},
  author={Andrew Warrington and Arthur P C Spencer and Frank Wood},
We develop a stochastic whole-brain and body simulator of the nematode roundworm Caenorhabditis elegans (C. elegans) and show that it is sufficiently regularizing to allow imputation of latent membrane potentials from partial calcium fluorescence imaging observations. This is the first attempt we know of to "complete the circle," where an anatomically grounded whole-connectome simulator is used to impute a time-varying "brain" state at single-cell fidelity from covariates that are measurable in… 

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