The Viral Connection to Glioblastoma

  title={The Viral Connection to Glioblastoma},
  author={J. Ricardo McFaline-Figueroa and Patrick Yung Wen},
  journal={Current Infectious Disease Reports},
Purpose of ReviewThe high incidence of and mortality from glioblastoma are matched by a lack of effective therapies. Previous research suggests an association between viral infection and glioma formation. In this manuscript, we review the available evidence for this association and the efficacy of treatment strategies targeted against viral infection.Recent FindingsWe find that while a wide array of viruses can drive glioma tumor formation in vitro and in xenograft models, the most convincing… 
Impact of human cytomegalovirus on glioblastoma cell viability and chemotherapy treatment.
It is demonstrated that GBM cell lines are equally susceptible but differentially permissive to infection by both low- and high-passage strains of HCMV, and that the virus reduces tumour cell viability in both the absence and presence of TMZ or BNCU.
The Role of Human Cytomegalovirus Infection in Glioblastoma Multiforme Pathogenesis: Review of the Literature
Previous researches have shown the presence of Human Cytomegalovirus nucleic acids and Proteins in GBM tumor tissue, suggesting that the virus may implicate in its pathogenesis, by affecting tumor stem cell factors, angiogenesis and immune pathways, but this association remains controversial.
Prospective investigation of herpesvirus infection and risk of glioma
Evidence of an inverse association between exposure to EBV and glioma is reported and it is reported that CMV exposure may be related to a higher likelihood of the nonglioblastoma subtype.
Lack of human cytomegalovirus expression in single cells from glioblastoma tumors and cell lines
This work rigorously test for HCMV RNA expression at a single cell level in GBM samples and examine the possible utility of single cell data in tumor virology.
MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2
  • Yan Wang, P. Zhao, Bin Wang
  • Biology, Medicine
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 2017
Data provide compelling evidence that human cytomegalovirus reduced the level of microRNA-613 which functions as an anti-onco-miRNA in glioblastoma, primarily by downregulating the expression of arginase-2.
Viral oncogenesis in tumours of the central nervous system: reality or random association? A retrospective study on archived material
The study reveals a positive correlation between HPV presence and glioma malignancy, and a negative correlation with meningioma grading, and suggests that the presence of HPV seems to be significantly associated with primary tumours of the CNS and its meninges.
Molecular Investigation of Human Cytomegalovirus and Epstein-Barr virus in Glioblastoma Brain Tumor: A Case-Control Study in Iran.
Investigation of molecular prevalence of HCMV and EBV infections in patients with GBM indicates that infection with EBV is associated with G BM.
Potential Therapeutic Approaches Against Brain Diseases Associated with Cytomegalovirus Infections
The advanced research for developing anti-CMV agents and approaches is promising to obtain significant outcomes and expecting to have a great impact on the therapy of brain diseases associated with CMV infections.
Cholesterol Derivatives as Promising Anticancer Agents in Glioblastoma Metabolic Therapy
The potential of targeting cholesterol metabolism using cholesterol derivatives as a pharmacological alternative to current therapeutic strategy for glioblastoma is discussed.


The story of human cytomegalovirus and cancer: increasing evidence and open questions.
The currently available knowledge about the molecular mechanisms that may contribute to oncomodulation by HCMV as well as the clinical findings that suggest that a fraction of tumors from different entities is indeed infected with H CMV are summarized.
Cidofovir: A Novel Antitumor Agent for Glioblastoma
A novel antiglioma property of the FDA-approved drug CDV is identified, which heightens the cytotoxic effect of radiotherapy, the standard of care therapy for glioblastoma.
Lack of association of herpesviruses with brain tumors
The hypothesis of an association of herpesviruses with the development of primary brain tumors is not supported andSerological analyses of brain tumor patients showed no significant differences in the prevalences of antibodies to HCMV, HSV, EBV, or VZV compared to the general population.
The legend of cytomegalovirus and glioblastoma lives on.
On current evidence there is no justification to expose glioblastoma patients to valganciclovir outside a clinical trial, and to demonstrate efficacy of anti-cytomegalovirus strategies in gliOBlastoma needs well-designed prospective studies avoiding claims that are potentially misleading.
RE: “Lack of association of herpesviruses with brain tumors”
Technical issues described in the article should be addressed to allow more accurate evaluation of the findings and to allow extreme technical proficiency and scientific scrutiny when examining potential causes of glioma.
Discordant humoral and cellular immune responses to Cytomegalovirus (CMV) in glioblastoma patients whose tumors are positive for CMV
In GBM patients, H CMV activity is higher than in healthy controls and serology is a poor test to define previous or active HCMV infection in these patients, according to a randomized, placebo-controlled trial of valganciclovir.
Human cytomegalovirus infection and expression in human malignant glioma.
It is shown that a high percentage of malignant gliomas are infected by HCMV and multiple H CMV gene products are expressed in these tumors and suggest that HCMVs may play an active role in glioma pathogenesis.
Lack of association of cytomegalovirus with human brain tumors
The findings of the present study suggest that CMV is not significantly associated with brain tumors in humans.
The detection of CMV pp65 and IE1 in glioblastoma multiforme
Immunohistochemical analysis of paraffin embedded tissue sections was performed on 49 newly diagnosed GBM tumors, with the possibility that CMV positive tumor cells can be recognized by CMV pp65/IE1 specific T cells.