The Viral Connection to Glioblastoma

@article{McFalineFigueroa2017TheVC,
  title={The Viral Connection to Glioblastoma},
  author={J. Ricardo McFaline-Figueroa and Patrick Yung Wen},
  journal={Current Infectious Disease Reports},
  year={2017},
  volume={19},
  pages={1-5}
}
Purpose of ReviewThe high incidence of and mortality from glioblastoma are matched by a lack of effective therapies. Previous research suggests an association between viral infection and glioma formation. In this manuscript, we review the available evidence for this association and the efficacy of treatment strategies targeted against viral infection.Recent FindingsWe find that while a wide array of viruses can drive glioma tumor formation in vitro and in xenograft models, the most convincing… 
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Citation Type

Impact of human cytomegalovirus on glioblastoma cell viability and chemotherapy treatment.
TLDR
It is demonstrated that GBM cell lines are equally susceptible but differentially permissive to infection by both low- and high-passage strains of HCMV, and that the virus reduces tumour cell viability in both the absence and presence of TMZ or BNCU.
The Role of Human Cytomegalovirus Infection in Glioblastoma Multiforme Pathogenesis: Review of the Literature
TLDR
Previous researches have shown the presence of Human Cytomegalovirus nucleic acids and Proteins in GBM tumor tissue, suggesting that the virus may implicate in its pathogenesis, by affecting tumor stem cell factors, angiogenesis and immune pathways, but this association remains controversial.
Prospective investigation of herpesvirus infection and risk of glioma
TLDR
Evidence of an inverse association between exposure to EBV and glioma is reported and it is reported that CMV exposure may be related to a higher likelihood of the nonglioblastoma subtype.
Lack of human cytomegalovirus expression in single cells from glioblastoma tumors and cell lines
TLDR
This work rigorously test for HCMV RNA expression at a single cell level in GBM samples and examine the possible utility of single cell data in tumor virology.
The Influence of Patient Sex on Clinical Approaches to Malignant Glioma.
MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2
  • Yan Wang, P. Zhao, Bin Wang
  • Biology, Medicine
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 2017
TLDR
Data provide compelling evidence that human cytomegalovirus reduced the level of microRNA-613 which functions as an anti-onco-miRNA in glioblastoma, primarily by downregulating the expression of arginase-2.
Viral oncogenesis in tumours of the central nervous system: reality or random association? A retrospective study on archived material
TLDR
The study reveals a positive correlation between HPV presence and glioma malignancy, and a negative correlation with meningioma grading, and suggests that the presence of HPV seems to be significantly associated with primary tumours of the CNS and its meninges.
Molecular Investigation of Human Cytomegalovirus and Epstein-Barr virus in Glioblastoma Brain Tumor: A Case-Control Study in Iran.
TLDR
Investigation of molecular prevalence of HCMV and EBV infections in patients with GBM indicates that infection with EBV is associated with G BM.
Potential Therapeutic Approaches Against Brain Diseases Associated with Cytomegalovirus Infections
TLDR
The advanced research for developing anti-CMV agents and approaches is promising to obtain significant outcomes and expecting to have a great impact on the therapy of brain diseases associated with CMV infections.
Cholesterol Derivatives as Promising Anticancer Agents in Glioblastoma Metabolic Therapy
TLDR
The potential of targeting cholesterol metabolism using cholesterol derivatives as a pharmacological alternative to current therapeutic strategy for glioblastoma is discussed.
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