The VirB/VirD4 type IV secretion system of Bartonella is essential for establishing intraerythrocytic infection.

@article{Schulein2002TheVT,
  title={The VirB/VirD4 type IV secretion system of Bartonella is essential for establishing intraerythrocytic infection.},
  author={Ralf Schulein and Christoph Dehio},
  journal={Molecular microbiology},
  year={2002},
  volume={46 4},
  pages={1053-67}
}
Bartonellae are pathogenic bacteria uniquely adapted to cause intraerythrocytic infection in their human or animal reservoir host(s). Experimental infection of rats by Bartonella tribocorum revealed the initial colonization of a yet unidentified niche outside of circulating blood. This primary niche periodically seeds bacteria into the bloodstream, resulting in the invasion and persistent intracellular colonisation of erythrocytes. Here, this animal model was used for a genetic analysis of the… CONTINUE READING

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