The VicRK system of Streptococcus mutans responds to oxidative stress.

  title={The VicRK system of Streptococcus mutans responds to oxidative stress.},
  author={Dong Mei Deng and Maojun Liu and Jacob Bob M Ten Cate and Wim Crielaard},
  journal={Journal of dental research},
  volume={86 7},
In Streptococcus mutans, virulence and cariogenicity may be modulated via the two-component regulatory system VicRK. Environmental signals, sensed by VicK, inducing this modulation are still unclear, however, and were investigated in the present study. We found that VicRK displays homology with protein-domains that, in other bacteria, are involved in redox-sensing. After constructing a VicRK-promoter GFP-reporter strain, we showed increased fluorescence intensity under oxidative stress… CONTINUE READING

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