The Vertebrate Ndc80 Complex Contains Spc24 and Spc25 Homologs, which Are Required to Establish and Maintain Kinetochore-Microtubule Attachment

Abstract

How kinetochores bind to microtubules and move on the mitotic spindle remain unanswered questions. Multiple systems have implicated the Ndc80/Hec1 (Ndc80) kinetochore complex in kinetochore-microtubule interaction and spindle checkpoint activity. In budding yeast, Ndc80 copurifies with three additional interacting proteins: Nuf2, Spc24, and Spc25. Although… (More)
DOI: 10.1016/j.cub.2003.12.058

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@article{McCleland2004TheVN, title={The Vertebrate Ndc80 Complex Contains Spc24 and Spc25 Homologs, which Are Required to Establish and Maintain Kinetochore-Microtubule Attachment}, author={Mark L. McCleland and Marko Johannes Kallio and Gregory A. Barrett-Wilt and Cortney A. Kestner and Jeffrey Shabanowitz and Donald F. Hunt and Gary J Gorbsky and P. Todd Stukenberg}, journal={Current Biology}, year={2004}, volume={14}, pages={131-137} }