The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing

@article{Billadeau1998TheVP,
  title={The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing },
  author={Daniel D Billadeau and Kathryn M. Brumbaugh and Christopher J. Dick and Renee A. Schoon and Xos{\'e} R Bustelo and Paul J. Leibson},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={549 - 559}
}
The Rac1 guanine nucleotide exchange factor, Vav, is activated in hematopoietic cells in response to a large variety of stimuli. The downstream signaling events derived from Vav have been primarily characterized as leading to transcription or transformation. However, we report here that Vav and Rac1 in natural killer (NK) cells regulate the development of cell-mediated killing. There is a rapid increase in Vav tyrosine phosphorylation during the development of antibody-dependent cellular… CONTINUE READING

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