The Value of Umbilical Cord Blood Bilirubin Measurement in Predicting the Development of Significant Hyperbilirubinemia in Healthy Newborn

  title={The Value of Umbilical Cord Blood Bilirubin Measurement in Predicting the Development of Significant Hyperbilirubinemia in Healthy Newborn},
  author={Zakia Nahar and Abdul Mannan and Sanjoy Dey and Ujjal Mitra and S M Selimuzzaman},
  journal={Bangladesh Journal of Child Health},
The present study was conducted to investigate the predictability of early serum bilirubin levels on the subsequent development of neonatal hyperbilirubinemia. For this purpose 84 healthy newborn infants were enrolled and followed up for first 5 days of life. Study subjects were divided into two groups. Group-I consisted of 71 subjects, who did not develop significant hyperbilirubinemia (bilirubin 17 mg/dl) during the follow up. Of the enrolled subjects, 46 (55%) were male and rest 38 (45… 

Umbilical Cord Blood Bilirubin Level Measurement in Predicting the Development of Significant Hyperbilirubinemia

It is led to the conclusion that the bilirubin levels that were equal to or greater than 2 mg/100 ml umbilical cord blood can predict significant hyperbilirubinemia with high negative and positive predictive values and high levels of sensitivity and specificity.

Evaluation of the Predictive Value of Umbilical Cord Serum Bilirubin Level for the Development of Subsequent Hyperbilirubinemia in Term and Late-Preterm Neonates

The best predictive marker for neonatal jaundice is the assessment of clinical risk factors and predischarge bilirubin level, which could not predict subsequent hyperbilirubinemia.

Predictive value of cord blood bilirubin in development of neonatal hyperbilirubinemia

Total serum bilirubin in cord blood was indicative of the jaundice severity among neonates and NNH and CBB level were found to be associated with several maternal and neonatal risk factors.

Umbilical Cord Bilirubin-an Early Diagnostic Marker of Significant Neonatal Hyperbilirubinemia

Background: To study the correlation between umbilical cord blood bilirubin and significant neonatal hyperbilirubinemia in healthy term newborns. Methods: The cord blood bilirubin estimation was done

Factors and Assays Identifying Babies at Riskto Develop Significant Hyperbilirubinemia

There was statistically significant relation between cord bilirubsin level, first day bilirubin level and subsequent hyperbilirubinemia (P 2.38 mg/dL or first day (TSB)>5 mg/ dL) and newborns should be followed up in the first 3 days of life.


Umbilical cord blood bilirubin ≥ 3mg/dl in healthy term babies can help in prediction of significant jaundice and thus can helpIn identifying high risk new-borns so that these neonates can be followed up more closely, it can also help in identifying neonates who are not at increased risk of developing significantJaundice, hence can prevent unnecessary hospital stay.

Cord bilirubin as a Predictor of Neonatal Hyper bilirubinemia in healthy term babies

Cord bilirubin can be a good predictor of hyperbilirubinemia and Neonates with cord bilirUBin < 2mg/dl are probably safe for early discharge and those with bilirutin levels >2 mg/dl need close follow up.

Role of Cord Blood Albumin and Bilirubin for Prediction of Significant Neonatal Jaundice

Cord blood bilirubin was found to be highly sensitive for early recognition of significant neonatal hyperbilirubinemia as compared to cord blood albumin and can be used for screening purpose.

To Assess Predictive Value of Cord Blood Bilirubin and Albumin for Significant Neonatal Hyperbilirubinemia: A Prospective Study from India

Cord bilirubin and albumin can be used as predictor for hyperbilirubinemia and for early review for jaundice especially in developing countries where regular follow up is difficult.

Study of Correlation of Cord Blood Bilirubin with Neonatal Hyperbilirubinemia

A 100% Negative Predictive Value in the present study suggests that in Healthy Term babies (without RH and ABO incompatibility with Cord Blood Bilirubin ≤3mg/dl) cord serum bilirubIN can help to identify those newborns who are unlikely to require further evaluation and intervention.

The Value of First-Day Bilirubin Measurement in Predicting the Development of Significant Hyperbilirubinemia in Healthy Term Newborns

A serum bilirubsin measurement and the use of the critical bilirubin level of 6 mg/dL in the first 24 hours of life will predict nearly all of the term newborns who will have significant hyperbilirubinemia and will determine all those who will require a phototherapy treatment later during the first days of life.

Early prediction of neonatal hyperbilirubinemia

By using serum bilirubin level measured 18 to 24 hours after birth as the “prediction test”, approximately two-thirds of neonates were test negative and had about one in ten chances of re-admission for treatment of hyperbilirubinemia, if discharged.

Bilirubin dosage in cord blood: could it predict neonatal hyperbilirubinemia?

Cord blood could be collected, stored and used for further analysis of unconjugated bilirubin levels as a means for considering whether or not to discharge a moderately jaundiced child from hospital, in association with other resources.

Predictive Ability of a Predischarge Hour-specific Serum Bilirubin for Subsequent Significant Hyperbilirubinemia in Healthy Term and Near-term Newborns

An hour-specific predischarge serum bilirubin measurement before hospital discharge can predict which newborn is at high, intermediate or low risk for developing clinically significant hyperbilirubinemia (specifically defined as TSB levels ≥95th percentile for age in hours).

Practice Parameter: Management of Hyperbilirubinemia in the Healthy Term Newborn

Most studies have failed to substantiate significant associations between a specific level of total serum bilirubin (TSB) during nonhemolytic hyperbilirubinemia in term newborns and subsequent IQ or serious neurologic abnormality (including hearing impairment).

Spectrum of neonatal hyperbilirubinemia: an analysis of 454 cases.

A prospective study of 454 newborn babies with pathological hyperbilirubinemia revealed that in about one-third of cases (34.6%) no cause could be identified despite detailed investigations, and there was no death attributable to the procedure of exchange blood transfusion.

Interrelationships Among Abnormal Cardiotocograms in Labor, Meconium Staining of the Amniotic Fluid, Arterial Cord Blood pH, and Apgar Scores

The current practice of considering cardiotocogram abnormality, meconium staining of the amniotic fluid, acidosis, and low Apgar scores as indicating one single disorder, “fetal distress,” is not valid.

Biochemical indices of nutritional status in maternal, cord, and early neonatal blood.

The nutritional status of 556 infants born in good health was measured by selected biochemical parameters in maternal venous blood, in mixed arteriovenous cord blood at delivery, and in infant's

Meconium stained amniotic fluid in very low risk pregnancies at term gestation.

Kernicterus in otherwise healthy, breast-fed term newborns.

Although very rare, classic kernicterus can occur in apparently healthy, full-term, breast-fed newborns who do not have hemolytic disease or any other discernible cause for their jaundice.