The Value of Inflammatory Signals in Adaptive Immune Responses

@inproceedings{Banerjee2011TheVO,
  title={The Value of Inflammatory Signals in Adaptive Immune Responses},
  author={Soumya Jyoti Banerjee and Drew Levin and Melanie E. Moses and Frederick T. Koster and Stephanie Forrest},
  booktitle={ICARIS},
  year={2011}
}
Cells of the immune system search among billions of healthy cells to find and neutralize a small number of infected cells before pathogens replicate to sufficient numbers to cause disease or death. The immune system uses information signals to accomplish this search quickly. Ordinary differential equations and spatially explicit agent-based models are used to quantify how capillary inflammation decreases the time it takes for cytotoxic T lymphocytes to find and kill infected cells. We find that… 

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References

SHOWING 1-10 OF 25 REFERENCES
Modeling intercellular interactions in the peripheral immune system
TLDR
A spatially explicit simulator that tracks individual cell responses to local molecular signals is described, and the use of that simulator to study models of peripheral tissue dynamics in normal and disease conditions is used.
Lymphocyte traffic control by chemokines
TLDR
Recent developments in this area justify the hypothesis that the distinct migration patterns of lymphocytes throughout their life cycle are finely tuned by changing sets of chemokines that are selective for developmentally regulated chemokine receptors.
Quantifying the Early Immune Response and Adaptive Immune Response Kinetics in Mice Infected with Influenza A Virus
TLDR
This study provides a basis to better understand and predict influenza virus immunity and confirms that CD8+ CTLs are crucial for limiting infected cells, while virus-specific IgM regulates free IAV levels.
Dynamics of Influenza Virus Infection and Pathology
TLDR
A powerful role for innate immunity is indicated in controlling the rapid peak in virus shedding and target cell depletion in pandemic influenza, using detailed data from equine influenza virus infection as a model of human influenza based only on virus-shedding data.
Scale invariance of immune system response rates and times: perspectives on immune system architecture and implications for artificial immune systems
TLDR
It is demonstrated that the lymphatic network of the NIS efficiently balances local and global communication, and a new approach for Artificial Immune Systems (AIS) that uses a sub-modular architecture to facilitate distributed search is suggested.
Characterizing T Cell Movement within Lymph Nodes in the Absence of Antigen1
TLDR
Comparisons of simulations with experimental data provide estimates of key parameters that characterize T cell motion in vivo, suggesting that at an intersection a T cell will turn onto a new fiber ∼50% of the time.
Modular RADAR: An Immune System Inspired Search and Response Strategy for Distributed Systems
TLDR
It is hypothesized that the architecture of the NIS, composed of a hierarchical decentralized detection network of lymph nodes (LN) facilitates efficient search and response, and a modular RADAR (Robust Adaptive Decentralized search with Automated Response) strategy for distributed systems is proposed.
Influenza Virology: Current Topics
TLDR
The differences between avian and human susceptibilities to the newer avian influenzavirus strains are explained and the potential new target sites for antiviral drugs are detailed.
A Hybrid Agent Based and Differential Equation Model of Body Size Effects on Pathogen Replication and Immune System Response
TLDR
This research addresses how pathogen replication rates and Immune System response times are constrained by host body size and proposes a stage structured hybrid model that strikes a balance between the detailed representation of an ABM and computational tractability of an ODE.
Higher Level of Replication Efficiency of 2009 (H1N1) Pandemic Influenza Virus than Those of Seasonal and Avian Strains: Kinetics from Epithelial Cell Culture and Computational Modeling
TLDR
Compared pandemic influenza virus strains were compared by infecting human differentiated bronchial epithelial cells in air-liquid interface cultures at relatively low virus particle/cell ratios to provide relevant parameters for identifying and phenotyping potential pandemic strains.
...
1
2
3
...