The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression

@article{Hwang2006TheVP,
  title={The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression},
  author={Jen-Ping Hwang and Shih-Jen Tsai and C. J. Hong and Chen-Hong Yang and Jiing-Feng Lirng and Ya-Min Yang},
  journal={Neurobiology of Aging},
  year={2006},
  volume={27},
  pages={1834-1837}
}
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239 Citations
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239 Citations

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The Val66Met polymorphism of the brain‐derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients
  • J. Iga, S. Ueno, T. Ohmori
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
TLDR
The results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features ofMDD in a Japanese population.
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
TLDR
Elderly depressed white subjects have almost double the odds of having geriatric depression than do Val66 allele homozygotes, and this polymorphism was unrelated to other clinical characteristics of depression in later life.
Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression
The Brain-Derived Neurotrophic-Factor ( BDNF ) Val 66 Met Polymorphism Is Associated With Geriatric Depression : A Meta-Analysis
TLDR
The findings suggest the BDNF Met allele may confer increased risk for depression as individual age, and may be associated with reduced expression of brain-derived neurotrophic factor in the hippocampus.
The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans
TLDR
The association of BDNF single nucleotide polymorphism rs6265 and depression is supported, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.
  • S. Benjamin, D. Mcquoid, W. Taylor
  • Psychology, Biology
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2010
TLDR
The BDNF Val66Met polymorphism is not significantly associated with hippocampal volume or function in a geriatric population, and the authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals.
Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.
TLDR
Findings from animal studies that the hippocampus is involved in brain development and plasticity are supported, suggesting that Met-BDNF allele carriers might be at risk to develop smaller hippocampal volumes and may be susceptible to major depression.
Val66Met polymorphism and serum brain-derived neurotrophic factor concentration in depressed patients
TLDR
Serum BDNF was significantly lower in MDD patients than in normal control subjects and genotype did not significantly correlate with the BDNF serum levels in the MDD or control groups, suggesting that there is a decrease in serum BDNF levels in untreatedMDD patients.
Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression.
TLDR
The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner.
Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness
TLDR
It is suggested that even in otherwise healthy subjects, trait depression may contribute to the susceptibility of Met carriers to hippocampal grey matter loss.
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References

SHOWING 1-10 OF 23 REFERENCES
Association Study of a Brain-Derived Neurotrophic-Factor Genetic Polymorphism and Mood Disorders, Age of Onset and Suicidal Behavior
TLDR
It seems reasonable to suggest that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or the authors' Chinese sample, and that this association is ethnicity dependent.
Association Study of a Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Personality Trait and Intelligence in Healthy Young Females
TLDR
It is suggested that genetic variants of the BDNF gene may play a role in specific cognitive functions, but not in overall intelligence, as tested in a cohort of 114 healthy young Chinese females.
Association study of a brain‐derived neurotrophic‐factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response
TLDR
A trend to improved 4‐week‐fluoxetine antidepressant response was demonstrated for heterozygous patients in comparison to homozygous analogs, suggesting the BDNF polymorphism investigated plays no major role in the pathogenesis of MDD.
The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.
TLDR
Test for the presence of linkage disequilibrium between two polymorphisms in the BDNF gene and BP in 283 nuclear families found it unlikely that the actual risk-conferring allele is from these two sites, but suggests that a DNA variant in the vicinity of the BD NF locus confers susceptibility to BP.
Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
TLDR
The findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers.
Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode
TLDR
It is suggested that antidepressant treatment has a positive effect on serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders.
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
BDNF gene is a risk factor for schizophrenia in a Scottish population
TLDR
The present study examines two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP, and concludes that, although the val66met polymorphism has been reported to alter gene function, the risk may depend upon the haplotypic background on which the val/met variant is carried.
Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects.
TLDR
Findings of reduced expression of BDNF and trk B in postmortem brain in suicide subjects suggest that these molecules may play an important role in the pathophysiological aspects of suicidal behavior.
Evidence for a Relationship Between Genetic Variants at the Brain-Derived Neurotrophic Factor (BDNF) Locus and Major Depression
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