The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression
@article{Hwang2006TheVP, title={The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression}, author={Jen-Ping Hwang and S. Tsai and Chen-Jee Hong and Chen-Hong Yang and Yamin Yang}, journal={Neurobiology of Aging}, year={2006}, volume={27}, pages={1834-1837} }
Brain-derived neurotrophic-factor (BDNF), the most abundant of the neurotrophins in the brain, has been implicated in both major depression and cognitive function. This study examines the association between the BDNF-gene Val66Met polymorphism and depression susceptibility and severity, age-of-onset, cognitive function and suicidal attempt history in an elderly Chinese sample population. We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression… CONTINUE READING
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References
SHOWING 1-10 OF 23 REFERENCES
Association Study of a Brain-Derived Neurotrophic-Factor Genetic Polymorphism and Mood Disorders, Age of Onset and Suicidal Behavior
- Medicine, Psychology
- Neuropsychobiology
- 2003
- 218
Association Study of a Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Personality Trait and Intelligence in Healthy Young Females
- Psychology, Medicine
- Neuropsychobiology
- 2004
- 104
Association study of a brain‐derived neurotrophic‐factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response
- Medicine
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2003
- 222
The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.
- Biology, Medicine
- American journal of human genetics
- 2002
- 612
Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
- Chemistry, Medicine
- Molecular Psychiatry
- 2005
- 366
- PDF
Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode
- Psychology, Medicine
- Neuropsychobiology
- 2005
- 191
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
- Psychology, Medicine
- Psychiatry Research
- 2002
- 1,063
BDNF gene is a risk factor for schizophrenia in a Scottish population
- Psychology, Medicine
- Molecular Psychiatry
- 2005
- 265
- PDF
Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects.
- Psychology, Medicine
- Archives of general psychiatry
- 2003
- 689
- PDF
Evidence for a Relationship Between Genetic Variants at the Brain-Derived Neurotrophic Factor (BDNF) Locus and Major Depression
- Psychology, Medicine
- Biological Psychiatry
- 2005
- 289