The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression

  title={The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression},
  author={Jen-Ping Hwang and S. Tsai and Chen-Jee Hong and Chen-Hong Yang and Yamin Yang},
  journal={Neurobiology of Aging},
  • Jen-Ping Hwang, S. Tsai, +2 authors Yamin Yang
  • Published 2006
  • Psychology, Medicine
  • Neurobiology of Aging
  • Brain-derived neurotrophic-factor (BDNF), the most abundant of the neurotrophins in the brain, has been implicated in both major depression and cognitive function. This study examines the association between the BDNF-gene Val66Met polymorphism and depression susceptibility and severity, age-of-onset, cognitive function and suicidal attempt history in an elderly Chinese sample population. We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression… CONTINUE READING
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