The Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men.

@article{Jang2006TheVV,
  title={The Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men.},
  author={Yangsoo Jang and Oh Yoen Kim and Soo Jeong Koh and Jey Sook Chae and Young Guk Ko and Ji Young Kim and Hongkeun Cho and T H Jeong and Woo Song Lee and Jos{\'e} M. Ordov{\'a}s and Jong Ho Lee},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 9},
  pages={3521-7}
}
CONTEXT AND OBJECTIVE It is unclear whether lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) exerts a pro- or antiatherogenic effect on cardiovascular disease (CVD). We investigated the association between Lp-PLA(2) variant (V279F and A379V) and CVD in Korean men. DESIGN CVD patients (n = 532) and healthy controls (n = 670) were genotyped for the Lp-PLA(2) polymorphism (V279F and A379V). MAIN OUTCOME MEASURES We calculated odds ratio (OR) on CVD risk and measured anthropometries, lipid… CONTINUE READING

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