The Vacuolating Virus, S.V.40

@article{Sweet1960TheVV,
  title={The Vacuolating Virus, S.V.40},
  author={Benjamin Hersh Sweet and Maurice R. Hilleman},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1960},
  volume={105},
  pages={420 - 427}
}
  • B. H. Sweet, M. Hilleman
  • Published 1 November 1960
  • Biology
  • Proceedings of the Society for Experimental Biology and Medicine
Summary The newly discovered vacuolating virus, S.V.40, appears to be a common and essentially ubiquitous contaminant of rhesus monkey kidney cell cultures and a likely common contaminant of cynomolgus kidney cultures in which it develops to high titer without evident cytopathic change. The virus grows readily in grivet, vervet and patas kidney and in rhesus testicle cultures causing a unique cytopathology characterized by ballooning and intense vacuolation. Some biological and biophysical… 

Figures and Tables from this paper

Cell and molecular biology of simian virus 40: implications for human infections and disease.
TLDR
Critical assessment of virologic and epidemiologic data suggests a probable causative role for SV40 in certain human cancers, but additional studies are necessary to prove etiology.
Expression of SV40 Early Region Genes in Transgenic Mice
TLDR
This virus was a contaminant of the early poliovirus vaccines produced in rhesus monkey cells, and it was introduced into millions of children in schools and adults in the armed forces with no clear cases of tumors or disease in the human population resulting from this exposure, with one possible exception.
INTRODUCTION TO POLYOMAVIRUSES
  • Medicine, Biology
TLDR
The apparent ubiquity of BKV and JCV makes it difficult to correlate seropos-itivity for BKKV-or JCV-specific antibodies with specific disease states, such as cancer.
Simian virus 40, poliovirus vaccines, and human cancer: research progress versus media and public interests.
  • J. Butel
  • Biology, Medicine
    Bulletin of the World Health Organization
  • 2000
TLDR
Current knowledge about SV40 is reviewed and public responses to reports in the media are considered, which emphasized that there is great interest in the possibility of health risks today from vaccinations received in the past.
RECENT ADVANCES IN THE STUDY OF SIMIAN VIRUSES *
  • G. Hsiung
  • Biology
    Annals of the New York Academy of Sciences
  • 1969
TLDR
A scheme for the classification of simian viruses, the properties of the major simian virus groups, and the several areas in which important advances have been made in the study of these agents in the past few years are discussed.
Polyomaviruses and human diseases.
  • N. AhsanK. Shah
  • Medicine, Biology
    Advances in experimental medicine and biology
  • 2006
TLDR
An overview of polyomaviruses is provided and its association with human diseases is introduced and histopathologic demonstration of viral inclusions in the brain parenchyma and renal tubules are shown.
SV40 and the Lung
TLDR
The capacity of the virus to infect humans and to cause disease, particularly in the lung and its serosal membrane, the pleura, is reviewed.
Simian cytomegalovirus and contamination of oral poliovirus vaccines.
Early cytoplasmic vacuolization of African green monkey kidney cells by SV40
TLDR
The results suggest that the capacity to induce the ECV resides in a structural component(s) of SV 40 virion and the vacuolization is not associated with the replication of SV40.
Isolation of SV40 Virus and its Effect on Renal Function in African Green Monkeys
SV40 virus is of considerable concern, because it has been shown to be present in a number of samples of inactivated polio virus and adenovirus vaccines produced before 1960, and it is capable of
...
...

References

SHOWING 1-7 OF 7 REFERENCES
The monkey kingdom : an introduction to the primates
Diagnostic Procedures for Virus and Rickettsial Diseases
Discussion, Second Internat
  • Am. Hlth. Org. and W l d . Hlth
  • 1960
Viral and Rickettsia1 In- frctions of Man
  • J. R. Lippincott Co., Philadelphia,
  • 1959
Production and Testing Requirements for Live Poliovirus Vaccine, Nat
  • 1960
Conf. on Produc- tion and Testing Requirements for Live Poliovirus Vaccine
  • Nat. Inst. Health,
  • 1960
Second Inter- nat
  • Conference on Live Poliovirus Vaccines, Pan. Am. Hlth. Org. and WEd. Hlth
  • 1960