The Vacuolating Virus, S.V.40

  title={The Vacuolating Virus, S.V.40},
  author={Benjamin Hersh Sweet and Maurice R. Hilleman},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={420 - 427}
  • B. H. Sweet, M. Hilleman
  • Published 1 November 1960
  • Biology
  • Proceedings of the Society for Experimental Biology and Medicine
Summary The newly discovered vacuolating virus, S.V.40, appears to be a common and essentially ubiquitous contaminant of rhesus monkey kidney cell cultures and a likely common contaminant of cynomolgus kidney cultures in which it develops to high titer without evident cytopathic change. The virus grows readily in grivet, vervet and patas kidney and in rhesus testicle cultures causing a unique cytopathology characterized by ballooning and intense vacuolation. Some biological and biophysical… 

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