The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast.

@article{Horazdovsky1993TheVG,
  title={The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast.},
  author={Bruce F. Horazdovsky and Scott D Emr},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 7},
  pages={4953-62}
}
The Saccharomyces cerevisiae vacuolar protein sorting mutant, vps16, exhibits pleiotropic defects in vacuolar protein targeting and vacuole morphology. To understand the role of the VPS16 gene in vacuolar protein sorting and organelle assembly, a vps16 ts mutant was used to clone the wild-type gene. DNA sequence analysis identified a single open reading frame within a vps16 complementing DNA fragment, capable of encoding a protein of 92,000 Da. Hydrophobicity analysis indicates that the Vps16… CONTINUE READING

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