The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis.

  title={The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis.},
  author={Timothy D. Henry and Brian Herb Annex and George R. McKendall and Michael A Azrin and John J. Lopez and Frank J. Giordano and Prediman Krishan Shah and James T. Willerson and Raymond L. Benza and Daniel S. Berman and C Michael Gibson and Alex Bajamonde and Amy Chen Rundle and Jennifer A. Fine and Edward R McCluskey},
  volume={107 10},
BACKGROUND Recombinant human vascular endothelial growth factor protein (rhVEGF) stimulates angiogenesis in animal models and was well tolerated in Phase I clinical trials. VIVA (Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis) is a double-blind, placebo-controlled trial designed to evaluate the safety and efficacy of intracoronary and intravenous infusions of rhVEGF. METHODS AND RESULTS A total of 178 patients with stable exertional angina, unsuitable for standard… CONTINUE READING
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