The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.

@article{Tosetto1997TheVP,
  title={The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.},
  author={Alberto Tosetto and Edoardo Missiaglia and Maurizio Frezzato and Francesco Rodeghiero},
  journal={British journal of haematology},
  year={1997},
  volume={97 4},
  pages={
          804-6
        }
}
We evaluated the hypothesis that a common polymorphism of the methylenetetrahydrofolate reductase gene (C677T), which results in increased levels of plasma homocysteine, may be a putative risk factor for venous thromboembolism (VT). Sixty-five cases of VT and 130 controls, both identified within the framework of an epidemiologic survey on thrombophilia, the Vicenza Thrombophilia and Arteriosclerosis (VITA) Project, were genotyped for the mutation. No increased risk of VT was found in carriers… CONTINUE READING

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