The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.

@article{Haase2005TheVT,
  title={The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.},
  author={Volker H Haase},
  journal={Seminars in cell & developmental biology},
  year={2005},
  volume={16 4-5},
  pages={564-74}
}
  • Volker H Haase
  • Published 2005 in Seminars in cell & developmental biology
The von Hippel-Lindau tumor suppressor pVHL plays a critical role in the pathogenesis of familial and sporadic clear cell carcinomas of the kidney and hemangioblastomas of the retina and central nervous system. pVHL targets the oxygen sensitive alpha subunit of hypoxia-inducible factor (HIF) for proteasomal degradation, thus providing a direct link between tumorigenesis and molecular pathways critical for cellular adaptation to hypoxia. Cell type specific gene targeting of VHL in mice has… CONTINUE READING