The VH and CH immunoglobulin genes of swine: implications for repertoire development.

@article{Butler1996TheVA,
  title={The VH and CH immunoglobulin genes of swine: implications for repertoire development.},
  author={John E. Butler and Jishan Sun and Imre Kacskovics and William R. A. Brown and Paloma Navarro},
  journal={Veterinary immunology and immunopathology},
  year={1996},
  volume={54 1-4},
  pages={7-17}
}
Swine have the largest number of IgG subclass genes of all species so far studied but have a single gene for IgA which occurs in two allelic forms that differ in hinge length. Swine also have constant region genes for C mu and C epsilon, but lack a gene homologous to that which encodes IgD in rodents and primates, despite the otherwise high degree of sequence similarity of all other swine CH genes with those of humans. Swine have < 20 VH genes, a single JH and perhaps a limited number of DH… CONTINUE READING