The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.

@article{Meyer2014TheVS,
  title={The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.},
  author={Hemmo Meyer and Conrad Chris Weihl},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 18},
  pages={3877-83}
}
The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important element of the ubiquitin system. Together with a network of cofactors, it regulates an ever-expanding range of processes that stretch into almost every aspect of cellular physiology. Its main role in proteostasis and key functions in signaling pathways are of relevance to degenerative diseases and genomic stability. In this Cell Science at a Glance and the accompanying poster, we give a brief overview of this… CONTINUE READING
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