The V1/V2 region of human immunodeficiency virus type 1 modulates the sensitivity to neutralization by soluble CD4 and cellular tropism.

@article{Morikita1997TheVR,
  title={The V1/V2 region of human immunodeficiency virus type 1 modulates the sensitivity to neutralization by soluble CD4 and cellular tropism.},
  author={T Morikita and Yosuke Maeda and Shigemoto Fujii and Shuzo Matsushita and Kenshi Obaru and Kiyoshi Takatsuki},
  journal={AIDS research and human retroviruses},
  year={1997},
  volume={13 15},
  pages={1291-9}
}
A primary isolate (KMT) of human immunodeficiency virus type 1 (HIV-1) resistant to recombinant soluble CD4 (rsCD4) was isolated from an HIV-1-infected individual and grown in a T lymphoid cell line. KMT isolate passaged on CEM cells (KMT/CEM) was still resistant to rsCD4. The V1/V2 and V3 regions of the viral envelope glycoprotein are thought to be involved in various biological phenotypes. To determine the exact envelope region of the KMT isolate responsible for sensitivity to rsCD4 and… CONTINUE READING
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