The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice.

@article{White1989TheVB,
  title={The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice.},
  author={Janice M. White and Andrew Herman and Andrew Mark Pullen and Ralph T. Kubo and John W. Kappler and Philippa Marrack},
  journal={Cell},
  year={1989},
  volume={56 1},
  pages={27-35}
}
Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice, this is because the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing V beta 3 and V beta 8.1, 8.2, and 8.3, and few others. Neonatal mice given the enterotoxin eliminate all mature, and some immature, T cells bearing these V beta s, demonstrating that tolerance to exogenously administered antigen… CONTINUE READING
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