The UvrD helicase and its modulation by the mismatch repair protein MutL

@article{Matson2006TheUH,
  title={The UvrD helicase and its modulation by the mismatch repair protein MutL},
  author={Steven W. Matson and Adam B. Robertson},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={4089 - 4097}
}
UvrD is a superfamily I DNA helicase with well documented roles in excision repair and methyl-directed mismatch repair (MMR) in addition to poorly understood roles in replication and recombination. The MutL protein is a homodimeric DNA-stimulated ATPase that plays a central role in MMR in Escherichia coli. This protein has been characterized as the master regulator of mismatch repair since it interacts with and modulates the activity of several other proteins involved in the mismatch repair… CONTINUE READING