The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review

  title={The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review},
  author={Darren M. Brenner and M. Moeller and William D. Chey and Philip Schoenfeld},
  journal={The American Journal of Gastroenterology},
OBJECTIVES:Irritable bowel syndrome (IBS) is a common disorder and available therapies have limited efficacy. Mucosal inflammation and alterations in gut microflora may contribute to the development of IBS symptoms, and researchers have hypothesized that probiotics might improve these symptoms. The aim of this study was to perform a systematic review of randomized controlled trials (RCTs) evaluating the efficacy, safety, and tolerability of probiotics in the treatment of IBS.METHODS… 

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.

Some probiotics are an effective therapeutic option for IBS patients, and the effects on each IBS symptom are likely species-specific, but future studies must focus on the role of probiotics in modulating intestinal microbiota and the immune system while considering individual patient symptom profiles.

Probiotics and irritable bowel syndrome

Though evidence is very promising, no general recommendations on the use of probiotics in IBS can be given yet because the heterogeneity of studies makes it difficult to compare the differences between probiotics and the effect may be strain-specific.

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Current data provides limited evidence for the efficacy of a small number of single-strain probiotics in IBS and sound studies following strict trial guidelines are needed.

Efficacy of probiotics in irritable bowel syndrome: A randomized, double blind placebo-controlled study

Probiotics effectively alleviates global IBS and improves TBS symptoms simultaneously with an improvement of quality of life.

The Efficacy and Safety of Rifaximin for the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis

It was found that studies with older patients and more females demonstrated higher response rates, which was consistent regardless of treatment group, and rifaximin proved more effective than placebo for global symptoms and bloating in IBS patients.

Irritable bowel syndrome: The role of probiotics in the systematic and successful treatment of irritable bowel syndrome

An interesting IBS case in a 50-year-old female of Indian origin who was successfully treated with precision Biotic culture designed by scientists specifically for targeted action and may help to ward off bad bacteria that cause IBS symptoms is reported.

Probiotics use to treat irritable bowel syndrome

Current evidences are almost enough to convince experts that probiotics are efficient in the treatment of IBS.

Effectiveness and Safety of Probiotics for Patients with Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of 10 Randomized Controlled Trials

The low-to-very low certainty evidence suggests that probiotics might improve the stool consistency of patients with IBS-C and increase the number of Bifidobacteria and Lactobacilli in feces with good safety, however, more high-quality studies with large samples are needed to verify the findings.

Effect of Multispecies Probiotic Supplementation on Irritable Bowel Syndrome

The beneficial effects of multispecies probiotic supplementation in controlling IBS patients’ abdominal pain showed it can be prescribed as a therapeutic option in addition to standard therapy and significantly lead to better control of this symptom in the short term.



Probiotics in The Treatment of Irritable Bowel Syndrome

  • A. Saggioro
  • Medicine
    Journal of clinical gastroenterology
  • 2004
In conclusion, short-term therapy with Lactobacillus PlantarumLP0 1 and Bifidocterium Breve BR0 may be considered a promising approach to the therapy for IBS.

Use of Diet and Probiotic Therapy in the Irritable Bowel Syndrome: Analysis of the Literature

  • M. Floch
  • Medicine
    Journal of clinical gastroenterology
  • 2005
Although investigations have shown that bran may be helpful in some patients, a complete review of the literature does not reveal conclusive evidence that diet therapy is effective in IBS and there appears to be a trend to decreasing symptoms.

A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome

LP299V seems to have a beneficial effect in patients with IBS, and further studies on larger cohorts of patients and with longer duration of therapy are required in order to establish the place of L. plantarum in the treatment of IBS.

Bacterial supplementation in the irritable bowel syndrome. A randomised double-blind placebo-controlled crossover study.

  • M. O'SullivanC. O'Morain
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2000

Single-blind follow-up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome.

Compared with baseline values and the control group, SCM-III resulted in a significant increase in lactobacilla, eubacteria and bifidobacteria, which suggests that some selected IBS patients could benefit substantially from symbiotics, but the treatment may need to be given on a cyclic schedule because of the temporary modification of the fecal flora.

Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.

B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.

The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowel Syndrome

Whether the nonabsorbed antibiotic rifaximin is more effective than placebo in reducing symptoms in adults with IBS is determined.