The Use of the Proteolytic Enzyme Brinase to Produce Autocytotoxicity in Patients with Acute Leukemia and Its Possible Role in Immunotherapy 1


Daily infusion of brinase (Protease 1 of Aspergillus oryzae) for 10 to 30 days in six patients (three children, three adults) with acute leukemia resulted in the production of complement-dependent autocytotoxicity against leukemic cells and lymphocytes and, in some instances, against platelets. This appeared to be due to the production of autoantibody, but… (More)

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