The Use of a Stably Expressed FRET Biosensor for Determining the Potency of Cancer Drugs

@inproceedings{Bozza2014TheUO,
  title={The Use of a Stably Expressed FRET Biosensor for Determining the Potency of Cancer Drugs},
  author={William P. Bozza and Xu Di and Kazuyo Takeda and Leslie A. Rivera Rosado and Sarah Pariser and Baolin Zhang},
  booktitle={PloS one},
  year={2014}
}
Many cancer drugs are intended to kill cancer cells by inducing apoptosis. However, the potency assays used for measuring the bioactivity of these products are generally cell viability assays which do not distinguish between cell death and growth inhibition. Here we describe a cell-based fluorescence resonance energy transfer (FRET) biosensor designed to… CONTINUE READING