The Use of a Multidimensional Measure of Dialysis Adequacy-Moving beyond Small Solute Kinetics.

@article{Perl2017TheUO,
  title={The Use of a Multidimensional Measure of Dialysis Adequacy-Moving beyond Small Solute Kinetics.},
  author={Jeffrey Perl and Laura M Dember and Joanne M. Bargman and Teri Browne and David M. Charytan and Jennifer E Flythe and LaTonya J Hickson and Adriana M Hung and M. Jadoul and Timmy Lee and Klemens B Meyer and Hamid Moradi and Tariq Shafi and Isaac Teitelbaum and Leslie P Wong and Christopher T. Chan},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2017},
  volume={12 5},
  pages={839-847}
}
Urea removal has become a key measure of the intensity of dialysis treatment for kidney failure. Small solute removal, exemplified by Kt/Vurea, has been broadly applied as a means to quantify the dose of thrice weekly hemodialysis. Yet, the reliance on small solute clearances alone as a measure of dialysis adequacy fails fully to quantify the intended clinical effects of dialysis therapy. This review aims to (1) understand the strengths and limitations of small solute kinetics as a surrogate… CONTINUE READING
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