The Use of TDM Data to Assess the Validity of Defined Daily Doses of Antiepileptics: A Comparison Between a Czech and Swedish University Hospital

@article{Koristkova2006TheUO,
  title={The Use of TDM Data to Assess the Validity of Defined Daily Doses of Antiepileptics: A Comparison Between a Czech and Swedish University Hospital},
  author={Blanka Koristkova and Folke Sj{\"o}qvist and Milan Grundmann and Ulf Bergman},
  journal={Therapeutic Drug Monitoring},
  year={2006},
  volume={28},
  pages={589-593}
}
Prescribed daily doses (PDDs) of antiepileptic drugs (AED) (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospitals in Ostrava, Czech Republic and Huddinge, Sweden. Plasma concentrations were used as an indicator of the quality of treatment. PDDs were compared with the defined daily doses (DDDs) suggested by WHO in the ATC/DDD index 2005. Request and reply forms for therapeutic drug monitoring (TDM) were used as a source of mean PDDs… 
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