The Use of Synthetic Peptides in the Formation of Biophysically and Biologically Active Pulmonary Surfactants

@article{Revak1991TheUO,
  title={The Use of Synthetic Peptides in the Formation of Biophysically and Biologically Active Pulmonary Surfactants},
  author={S. Revak and T. Merritt and M. Hallman and G. Heldt and Robert J La Polla and K. Hoey and R. Houghten and C. Cochrane},
  journal={Pediatric Research},
  year={1991},
  volume={29},
  pages={460-465}
}
ABSTRACT: Synthetic pulmonary surfactants consisting of mixtures of phospholipids with synthetic peptides based on the amino acid sequence of human surfactant apoprotein SP-B were prepared. These surfactants were analyzed for their ability to lower surface tension on a pulsating bubble surfactometer and for their capacity to improve lung compliance and increase alveolar expansion in a fetal rabbit model of surfactant deficiency. The data demonstrate that several peptides, ranging from 17 to 45… Expand
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