The Use of Strictly Standardized Mean Difference for Hit Selection in Primary RNA Interference High-Throughput Screening Experiments

@article{Zhang2007TheUO,
  title={The Use of Strictly Standardized Mean Difference for Hit Selection in Primary RNA Interference High-Throughput Screening Experiments},
  author={Xiaohua Douglas Zhang and Marc Ferrer and Amy S. Espeseth and Shane D. Marine and Erica M. Stec and Michael A. Crackower and Daniel J. Holder and Joseph F. Heyse and Berta Strulovici},
  journal={Journal of Biomolecular Screening},
  year={2007},
  volume={12},
  pages={497 - 509}
}
RNA interference (RNAi) high-throughput screening (HTS) has been hailed as the 2nd genomics wave following the 1st genomics wave of gene expression microarrays and single-nucleotide polymorphism discovery platforms. Following an RNAi HTS, the authors are interested in identifying short interfering RNA (siRNA) hits with large inhibition/activation effects. For hit selection, the z-score method and its variants are commonly used in primary RNAi HTS experiments. Recently, strictly standardized… 
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The z-score method and its variants for testing mean difference are commonly used for hit selection in high-throughput screening (HTS) assays. Strictly standardized mean difference (SSMD) offers a
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