The Use of Patient-reported Outcomes (PRO) Within Comparative Effectiveness Research: Implications for Clinical Practice and Health Care Policy

@article{Ahmed2012TheUO,
  title={The Use of Patient-reported Outcomes (PRO) Within Comparative Effectiveness Research: Implications for Clinical Practice and Health Care Policy},
  author={Sara Ahmed and Richard A. Berzon and Dennis A. Revicki and William R. Lenderking and Carol M. Moinpour and Ethan M. Basch and Bryce B. Reeve and Albert W. Wu},
  journal={Medical Care},
  year={2012},
  volume={50},
  pages={1060–1070}
}
Background:The goal of comparative effectiveness research (CER) is to explain the differential benefits and harms of alternate methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. To inform decision making, information from the patient’s perspective that reflects outcomes that patients care about are needed and can be collected rigorously using appropriate patient-reported outcomes (PRO). It can be challenging to select the most appropriate… 
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The importance of and methods for using PROs for PCOR are described and the critical role of electronic data methods for facilitating the use of PRO data in PCOR is identified.
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TLDR
Organizations wishing to integrate PROs and EHRs should assemble the multidisciplinary expertise needed to evaluate the advantages and disadvantages of various approaches within three themes: Planning, Selection, and Engagement.
The importance of patient-reported outcomes: a call for their comprehensive integration in cardiovascular clinical trials.
TLDR
Cardiovascular clinical research should shift its focus to include PROs when evaluating the efficacy of therapeutic interventions, and PRO assessments should be scientifically rigorous.
ISOQOL recommends minimum standards for patient-reported outcome measures used in patient-centered outcomes and comparative effectiveness research
TLDR
The development of these minimum measurement standards is intended to promote the appropriate use of PRO measures to inform PCOR and CER, which in turn can improve the effectiveness and efficiency of healthcare delivery.
Evaluation of patient-reported outcome protocol content and reporting in UK cancer clinical trials: the EPiC study qualitative protocol
TLDR
This study will explore with key stakeholders factors that influence optimal PRO protocol content, implementation and reporting and make recommendations for training and guidance and whether these findings are applicable to UK cancer trials and if so, how to best enhance the way PROs are assessed, managed and reported in clinical trials.
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