The Use of NMDA‐Receptor Antagonists in the Treatment of Chronic Pain

  title={The Use of NMDA‐Receptor Antagonists in the Treatment of Chronic Pain},
  author={D. Hewitt},
  journal={The Clinical Journal of Pain},
  • D. Hewitt
  • Published 2000
  • Medicine
  • The Clinical Journal of Pain
  • Abstract: Chronic pain can be maintained by a state of sensitization within the central nervous system that is mediated in part by the excitatory amino acids glutamate and aspartate binding to the N‐methyl‐D‐aspartate (NMDA) receptor. A number of antagonists to the NMDA receptor are antinociceptive in animal models but are associated with significant dose‐limiting side effects. Commercially available NMDA‐receptor antagonists include ketamine, dextromethorphan, memantine, and amantadine. The… CONTINUE READING
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