The Use of Lysosomotropic Dyes to Exclude Lysosomal Membrane Permeabilization.

Abstract

Progressive lowering of pH is characteristic for the endocytic pathway and enables efficient degradation of molecules by hydrolytic enzymes at its distal end. The existence of the proton gradient over the endosomal/lysosomal membranes depends on the action of the vacuolar ATPase (v-ATPase). During lysosomal membrane permeabilization (LMP), protons leak… (More)
DOI: 10.1101/pdb.prot087106

1 Figure or Table

Topics

  • Presentations referencing similar topics