The Use of Lysosomotropic Dyes to Exclude Lysosomal Membrane Permeabilization.


Progressive lowering of pH is characteristic for the endocytic pathway and enables efficient degradation of molecules by hydrolytic enzymes at its distal end. The existence of the proton gradient over the endosomal/lysosomal membranes depends on the action of the vacuolar ATPase (v-ATPase). During lysosomal membrane permeabilization (LMP), protons leak… (More)
DOI: 10.1101/pdb.prot087106

1 Figure or Table


  • Presentations referencing similar topics