The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain

@article{Lange1995TheUO,
  title={The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain},
  author={Elizabeth C. de Lange and Jacques A. de Vries and Chris Zurcher and Meindert Danhof and Albertus Gerrit de Boer and D. D. Breimer},
  journal={Pharmaceutical Research},
  year={1995},
  volume={12},
  pages={1924-1931}
}
Purpose. The use of intracerebral microdialysis as a tool to measure the penetration of anticancer agents in brain tumor was investigated. Methods. Following intravenous (iv) administration of 75 mg/kg. concentration-time profiles of methotrexate (MTX) were determined in brain cortical dialysate and in plasma. The individual ratio of the area under the curve of MTX in brain dialysate over that in plasma (MTX penetration) was determined in normal brain, in tumor-bearing brain and in brain after… CONTINUE READING